Lignes couplées à ondes lentes intégrées sur silicium en bande millimétrique - Application aux coupleurs, filtres et baluns

This work focuses on high-performances CS-CPW (Coupled Slow-wave CoPlanar Waveguide) transmission lines in classical CMOS integrated technologies for the millimiter-wave frequency band. First, the theory as well as the electrical models of the CS-CPW are presented. Thanks to the models and electromagnetic simulations, directional couplers with different coupling levels (3 dB, 10 dB, 18 dB) were designed in BiCMOS 55 nm technology. They have a good directivity, always better than 15 dB. A first prototype of a coupler was measured at 150 GHz presenting good agreement with the simulations. Next, coupled-line base filters were developed at 80 GHz using the CS-CPWs. Simulation present competitive results with the state-of-art: 11% of fractional bandwidth and a unload quality factor of 25. Finally, three projects started based on the CS-CPWs. The projects are currently used in two theses and one internship: a RTPS at 47 GHz, an isolator at 75 GHz and a balun at 80 GHz.L’objectif de ce travail de thèse est le développement en technologie intégrée standard d’une structure de ligne de transmission optimisée en termes de pertes, d’encombrement, de facteur de qualité et surtout du choix du niveau de couplage aux fréquences millimétriques. Cette structure a été nommée CS-CPW (Coupled Slow-wave CoPlanar Waveguide). Dans un premier temps, la théorie ainsi que les modèles électriques des CS-CPW sont présentés. Grâce aux modèles et aux simulations électromagnétiques, des coupleurs directionnels avec plusieurs valeurs de couplage (3 dB, 10 dB, 18 dB) ont été conçus en technologie BiCMOS 55 nm. Ils présentent tous une très bonne directivité, elle est toujours supérieure à 15 dB. Un premier prototype de coupleur a été mesuré à 150 GHz. Dans un deuxième temps, des filtres à la base des lignes couplées ont été développés à 80 GHz en utilisant des lignes CS-CPW. Les résultats des simulations présentent des résultats concurrentiels avec l’état de l’art : 11% de bande passante relative et un facteur non-chargé autour de 25. Finalement, trois projets ont démarré à la base de ces lignes. Ces projets sont actuellement utilisés dans deux travaux de thèse et un stage : un RTPS à 47 GHz, un isolateur à 75 GHz et un balun à 80 GHz

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Background: Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods: For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings: Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8-13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05-6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation: Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life

Averting biodiversity collapse in tropical forest protected areas

The rapid disruption of tropical forests probably imperils global biodiversity more than any other contemporary phenomenon¹⁻³. With deforestation advancing quickly, protected areas are increasingly becoming final refuges for threatened species and natural ecosystem processes. However, many protected areas in the tropics are themselves vulnerable to human encroachment and other environmental stresses⁴⁻⁹. As pressures mount, it is vital to know whether existing reserves can sustain their biodiversity. A critical constraint in addressing this question has been that data describing a broad array of biodiversity groups have been unavailable for a sufficiently large and representative sample of reserves. Here we present a uniquely comprehensive data set on changes over the past 20 to 30 years in 31 functional groups of species and 21 potential drivers of environmental change, for 60 protected areas stratified across the world’s major tropical regions. Our analysis reveals great variation in reserve ‘health’: about half of all reserves have been effective or performed passably, but the rest are experiencing an erosion of biodiversity that is often alarmingly widespread taxonomically and functionally. Habitat disruption, hunting and forest-product exploitation were the strongest predictors of declining reserve health. Crucially, environmental changes immediately outside reserves seemed nearly as important as those inside in determining their ecological fate, with changes inside reserves strongly mirroring those occurring around them. These findings suggest that tropical protected areas are often intimately linked ecologically to their surrounding habitats, and that a failure to stem broad-scale loss and degradation of such habitats could sharply increase the likelihood of serious biodiversity declines.Keywords: Ecology, Environmental scienc

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Slow-wave coupled lines integrated over silicon in mm-wave band - Applications to couplers, filters and baluns

L’objectif de ce travail de thèse est le développement en technologie intégrée standard d’une structure de ligne de transmission optimisée en termes de pertes, d’encombrement, de facteur de qualité et surtout du choix du niveau de couplage aux fréquences millimétriques. Cette structure a été nommée CS-CPW (Coupled Slow-wave CoPlanar Waveguide). Dans un premier temps, la théorie ainsi que les modèles électriques des CS-CPW sont présentés. Grâce aux modèles et aux simulations électromagnétiques, des coupleurs directionnels avec plusieurs valeurs de couplage (3 dB, 10 dB, 18 dB) ont été conçus en technologie BiCMOS 55 nm. Ils présentent tous une très bonne directivité, elle est toujours supérieure à 15 dB. Un premier prototype de coupleur a été mesuré à 150 GHz. Dans un deuxième temps, des filtres à la base des lignes couplées ont été développés à 80 GHz en utilisant des lignes CS-CPW. Les résultats des simulations présentent des résultats concurrentiels avec l’état de l’art : 11% de bande passante relative et un facteur non-chargé autour de 25. Finalement, trois projets ont démarré à la base de ces lignes. Ces projets sont actuellement utilisés dans deux travaux de thèse et un stage : un RTPS à 47 GHz, un isolateur à 75 GHz et un balun à 80 GHz.This work focuses on high-performances CS-CPW (Coupled Slow-wave CoPlanar Waveguide) transmission lines in classical CMOS integrated technologies for the millimiter-wave frequency band. First, the theory as well as the electrical models of the CS-CPW are presented. Thanks to the models and electromagnetic simulations, directional couplers with different coupling levels (3 dB, 10 dB, 18 dB) were designed in BiCMOS 55 nm technology. They have a good directivity, always better than 15 dB. A first prototype of a coupler was measured at 150 GHz presenting good agreement with the simulations. Next, coupled-line base filters were developed at 80 GHz using the CS-CPWs. Simulation present competitive results with the state-of-art: 11% of fractional bandwidth and a unload quality factor of 25. Finally, three projects started based on the CS-CPWs. The projects are currently used in two theses and one internship: a RTPS at 47 GHz, an isolator at 75 GHz and a balun at 80 GHz

Coupleurs directifs et filtres millimétriques utilisant des coupleurs innovants basés sur des lignes à ondes lentes couplées en technologie BiCMOS avancée

National audienc

Application en millimétrique des guides coplanaires couplés à ondes lentes intégrés en silicium : coupleurs directionnels et filtres

National audienc

Application en millimétrique des guides coplanaires couplés à ondes lentes intégrés en silicium : coupleurs directionnels et filtres

National audienc

Conception d’un « Reflection-Type Phase Shifter » en technologie BiCMOS 55nm. Application à l’orientation de faisceau en bande millimétrique

National audienc

A 270-to-300 GHz LO-Path Phase Shifting Architecture for Sub-mm-wave Phased Arrays

International audienc